Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption
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چکیده
منابع مشابه
Evaluating Different Approaches to Permeability Prediction in a Carbonate Reservoir
Permeability can be directly measured using cores taken from the reservoir in the laboratory. Due to high cost associated with coring, cores are available in a limited number of wells in a field. Many empirical models, statistical methods, and intelligent techniques were suggested to predict permeability in un-cored wells from easy-to-obtain and frequent data such as wireline logs. The main obj...
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The cellobiose and mannitol differential sugar test is a non-invasive investigation of small bowel permeability, in which urinary recoveries of cellobiose and mannitol after a hyperosmolar oral load are expressed as a ratio to give a permeability index. Changes in the cellobiose:mannitol ratio often occur in coeliac disease, but some patients with abnormal permeability have normal jejunums by r...
متن کاملComputational approaches for modeling human intestinal absorption and permeability
Human intestinal absorption (HIA) is an important roadblock in the formulation of new drug substances. Computational models are needed for the rapid estimation of this property. The measurements are determined via in vivo experiments or in vitro permeability studies. We present several computational models that are able to predict the absorption of drugs by the human intestine and the permeabil...
متن کاملGeography of intestinal permeability and absorption.
BACKGROUND Intestinal morphology and function vary geographically. AIMS These functions were assessed in asymptomatic volunteers in European, North American, Middle Eastern, Asian, African, and Caribbean countries. METHODS Five hour urine collections were obtained from each subject following ingestion of a 100 ml iso-osmolar test solution containing 3-0-methyl-D-glucose, D-xylose, L-rhamnos...
متن کاملPermeability Prediction Using a Multigrid Method
A finite difference based Stokes solver is developed to predict the mesoscopic permeability of textile reinforcements. In general, a high grid resolution is employed (either globally or locally) to capture the geometrical details of the reinforcement. Local grid refinements often result in poor aspect ratios of the elements, resulting in inaccurate results, whereas the computational cost of com...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2015
ISSN: 1550-7416
DOI: 10.1208/s12248-015-9758-0